REN and prion disease: The analysis of the KEGG pathway revealed that the foremost ten pathways identified consisted of complement and coagulation cascades, systemic lupus erythematosus, staphylococcus aureus infection, protein digestion and absorption, pertussis, steroid hormone biosynthesis, renin-angiotensin system, antigen processing and presentation, prion diseases, and vitamin digestion and absorption (Figure 6C, Table S3).