Fusion of androgen-regulated transmembrane protease serine 2 (TMPRSS2) and ETS transcription factor, v-ets erythroblastosis virus E26 oncogene homolog (ERG) genes is a common somatic alteration in PC, resulting in overexpression of ERG oncogene, a member of the ETS transcription factor family [37,38]. This evidence concerns the gene TMPRSS2 and pachyonychia congenita.