The different roles of the paralogues EZH1 and EZH2 need to be further studied in PC; data in literature showed a different expression pattern for EZH1, found in dividing and differentiated cells, and EZH2, only present in highly proliferative cells [51,52] in T-cell lymphomas patients, but no data exist in prostate cancer. Here, EZH2 is linked to pachyonychia congenita.