BRCA1 and neoplasm: The main reasons for the loss of activity of the BRCA1 gene are aberrant expression, loss of heterozygosity of this gene, the presence of a deletion of the 17q21.31 locus in the tumor tissue, somatic mutations, promoter hypermethylation, etc. Relatively recently, a comparative study of the efficacy of carboplatin and docetaxel in patients with familial breast cancer and BRCA-like tumors was carried out.