Notably, all sNGS negative cases harbored mutant gene variants with prognostic significance at the WES level but only one specimen (case 4) harbored a potentially actionable FGFR3::TACC3 fusion that defines an unique molecular subtype of NSCLC and that may be amenable to targeted therapy [15,16]. The gene discussed is TACC3; the disease is non-small cell lung carcinoma.