The 39 downregulated pathways included “CXCR4 signaling”, “HIF1α signaling”, “Ephrin receptor signaling”, “acute myeloid leukemia signaling”, and “UVB-induced MAPK signaling” pathways, whereas there were only four upregulated pathways, including the “oxidative phosphorylation” and “cyclins and cell-cycle regulation” pathways (Tables S3–S5). Here, HIF1A is linked to acute myeloid leukemia.