CXCR4 and acute myeloid leukemia: Furthermore, pathway analysis with IPATM showed downregulation of “acute myeloid leukemia signaling”, as well as important pathways known for HSC maintenance and differentiation in Uhrf2−/− HSPCs, including “CXCR4 signaling” [29], “HIF-1α signaling” [30], and “Ephrin receptor signaling” [31].