FMR1 and autism: In this study, we focus on the role of FMR1 premutation alleles in ASD susceptibility by examining the largest available whole-genome sequence (WGS) datasets of ASD families with a total of 20,576 subjects, collected by the Simons Foundation Autism Research Initiative (SFARI), through the Simons Simplex Collection (SSC) [22] and the Simons Foundation Powering Autism Research (SPARK) initiative [23].