In this sense, it is crucial to highlight the importance of including dietary DHA, since it was observed that it is possible to increase the concentration of this fatty acid in the RBCs and is associated with having a positive impact by decreasing inflammatory markers such as MCP-1 and IL-8 in subjects with obesity in the context of higher adherence to a diet intervention. The gene discussed is CXCL8; the disease is obesity due to melanocortin 4 receptor deficiency.