PIK3CA and angioosteohypertrophic syndrome: The 2018 classification of the International Society for the Study of Vascular Anomalies (ISSVA) defines KTS as a syndrome with capillary and venous malformations and limb overgrowth, with or without lymphatic malformation, and includes the syndrome in the group of disorders belonging to the PIK3CA-related overgrowth spectrum (PROS) [15].