GM participates in the health–disease process of its host, so the present work aimed to evaluate the mediating role of waist circumference in the association between A. muciniphila, L. casei, L. paracasei, L.reuteri, and S. aureus with homeostatic model assessment for insulin resistance (HOMA-IR) and homeostatic model assessment for insulin resistance adiponectin-corrected (HOMA-AD) in Mexican children. This evidence concerns the gene ADIPOQ and Insulin resistance.