INS and Adrenal insufficiency: However, because glucagon is a potent insulin secretagogue, it is crucial to consider the previously reported studies that indicated that glucagon may result in rebound hypoglycemia [39]; furthermore, it is important to consider that the adrenal response was age-dependent and sex-dependent during the GST, associated with a high false-positive rate (23.7%), and resulted in the overdiagnosis of adrenal insufficiency in 190 children [40].