Additionally, the Down syndrome cohort demonstrated a proinflammatory state not present in matched controls, with higher mean body mass index (BMI) (26.0 vs. 23.5 kg/m2, p < 0.001) and C-reactive protein (CRP) levels (29.3 vs. 14.5 mg/L, p < 0.001). This evidence concerns the gene CRP and Down syndrome.