Although specific genes associated with VGAM are unknown, some genes are linked to VGAM coexistence with other syndromes, such as p120-RasGAP (RASA1) mutations in cutaneous malformations-arteriovenous malformations (CM-AVM), as well as isolated mutations in activin A receptor type II-like 1 (ACVRL1) and endoglin (ENG) in hereditary hemorrhagic telangiectasia [5]. The gene discussed is ENG; the disease is arteriovenous hemangioma/malformation.