KLK3 and Familial prostate cancer: Over the course of the last few years, commonly used tools for the detection of prostate cancer, such as the serum prostate-specific antigen (PSA), digital rectal examination (DRE) and prostate biopsy, have been supplemented with multiparameter magnetic resonance imaging (mpMRI) as well as mpMRI-guided biopsy of the prostate (Fbx) [2,3].