EPCAM and cancer: Finally, it should be noted that in our study, a statistically significant reduction in overall survival (OS) (p < 0.001) and disease-free survival (DFS) (p < 0.001) was observed in tumors with both perineural invasion and high levels of EpCAM expression (PNI+/EpCam+) compared to patients with PNI−/EpCam− cancers.