EMT, which stands for epithelial–mesenchymal transition, is a phenomenon in which epithelial cells convert into mesenchymal cells through losing epithelial cell–cell junction and epithelial markers (E-cadherin and γ-catenin) while inducing mesenchymal markers (Twist, Vimentin, Snail, and Slug) and is associated with facilitating migration and invasion of HCC tumor cells [108]. Here, TWIST1 is linked to hepatocellular carcinoma.