To this end, we conducted electronic research in the PubMed database using “neonatal sepsis” “AND biomarkers” OR “blood culture” OR “blood cell count” OR “immature-to-total neutrophil ratio” OR “platelet count” OR “c-reactive protein” or “CRP” or “procalcitonin” or “PCT” or “amyloid A” OR “proadrenomelullin” OR “inflammatory markers” OR “cytokine“ or “interleukin-6” or “Interleukin-8” OR “tumor necrosis factor” OR “presepsin” OR “soluble triggering receptor” OR “sTREM-1” OR “cluster differentiation molecule-64” OR “CD-64” OR “omics” as keywords. The gene discussed is IL6; the disease is Sepsis.