IL6 and Neonatal sepsis: It has been observed (177) that IL-6 (>400 pg/mL) alone or in combination with TNF-α (>32 pg/mL), IL-8 (>200 pg/mL), and granulocyte-colony stimulating factor (>1000 pg/mL) had 100% sensitivity, specificity, negative predictive value, and 38–69% positive predictive value to differentiate gram-negative neonatal sepsis [180].