In human aortic endothelial cells, transient hyperglycemia causes a cascade from increased protein phosphatase 2A (PP2A) activity to decreased Akt activity, increased glycogen synthase kinase (GSK)-3β activity and increased VDAC phosphorylation, which disrupts the interaction of VDAC with HK2 [153]. Here, VDAC1 is linked to Hyperglycemia.