CD8A and inclusion body myositis: Ongoing clinical trials pertaining to IBM involve, for example, the ability of a monoclonal antibody against the KLRG1 receptor to deplete highly differentiated and cytotoxic CD8+ T cells (clinical trial code: NCT04659031), a rapamycin (previously approved to prevent rejection in organ transplantation and to treat certain types of cancer) that blocks effector T cells while preserving regulatory T cells and inducing autophagy (NCT04789070), and even stem cell muscle injections (NCT04975841) [1].