Neurodegenerative disorders, such as Alzheimer’s disease, are characterized by distinguishable histopathological hallmarks (Figure 1), including (1) pathological protein aggregation (e.g., Aβ and tau), (2) synaptic and neuronal network dysfunction, (3) aberrant proteostasis, (4) cytoskeletal abnormalities, (5) altered energy homeostasis, (6) DNA and RNA defects, (7) neuroinflammation, and (8) neuronal cell death [6]. The gene discussed is MAPT; the disease is Alzheimer disease.