MAPT and Alzheimer disease: SD determines alterations in multiple pathways that may lead to the pathology observed in AD, such as neuroinflammation and oxidative stress, endothelial damage, impaired glial pathway, inhibition of neurogenesis and cholinergic neurons, impairment of spatial and working memory, impairment of long-term potentiation and synaptic plasticity, decreased amyloid-β clearance and subsequent accumulation of amyloid-β and tau [114].