The involvement of DMPK-A in preventing ROS damage and apoptosis by forming a complex with HK-II and Src at the OMM [135], together with the reduction in DMPK expression in DM1 [130] can lead to think that a lack of DMPK-A may play part in mitochondrial damage in DM1. Here, HK2 is linked to myotonic dystrophy type 1.