ACSL4 and central nervous system cancer: Nevertheless, recent evidence has linked Drp1 to ACSL4-driven ferroptosis since the Hsp90-dependent Drp1 dephosphorylation at serine 637 (Ser637) stabilizes and binds ACSL4, thereby increasing its expression in glioma cells and regulating ferroptosis through the generation of lipid ROS and alterations in mitochondrial morphology [54].