TNF and Hepatic fibrosis: Based on the elevated expression levels of the p53 targets in the liver fibrosis models and a previous report that p53 activation triggers the apoptotic pathways in hepatocytes [42], we further focused on the regulation of the p53-associated apoptotic genes, such as Bax, Casp3, and Tnf, that are involved in the burn-wound-healing pathway (Figure 3B).