The results of our research suggest that during the progression of the aneurysm, and especially in the transitional stage in the group of patients with aneurysm diameter between 55 and 70 mm, the oxidative stress increases to such an extent that chronic activation of NRF2 is a source of redox homeostasis disturbance of cells, intensifying inflammatory processes and leading to non-linear development of the aneurysm, which may potentially lead to its rupture. This evidence concerns the gene NFE2L2 and aneurysm.