For example, induction of liver fibrosis by CCl4 is associated with increased expression in Kupffer cells of T-cell immunoglobulin domain and mucin domain-4 (TIM-4), a protein selectively expressed on antigen-presenting cells, together with augmented ROS production, mitophagy and TGF-β1 secretion. This evidence concerns the gene TIMD4 and Hepatic fibrosis.