PSP pathology is associated with some rare MAPT mutations, mainly in exon 10 (S285S, DN296, N297K, G303V, S303S, S305S) but also in intron 10 (IVS10 + 16) and exon 1 (R5L) or even in exon 12 (V363A) or exon 13 (R406W). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.