In fact, most studies carried out to determine the involvement of NRF2 in genomic instability are concerning cancer, where it has been described that NRF2 preserves genomic integrity by facilitating ataxia-telangiectasia-mutated and RAD3-related (ATR) activation and G2 cell cycle arrest [46] and plays a role in maintaining the integrity of the genome by modulating genes implicated in DNA repair [47]. This evidence concerns the gene NFE2L2 and cancer.