The involvement of PEBP-1 in the MAPK signaling is well documented in the studies showing that PEBP-1 promotes neuronal differentiation by binding to c-Raf and avoiding MEK phosphorylation, both in a human neuroblastoma cell line [70] and in adult rat hippocampal progenitor cells [71]. The gene discussed is PEBP1; the disease is neuroblastoma.