Several research works have provided ample evidence on the antiproliferative and proapoptotic properties of pomegranate products, such as the whole fruit, its juice, and oil, which exert anti-inflammatory, antiproliferative, and anti-tumor effects in different types of tumors via the modulation of multiple signaling pathways, such as NFkB, COX2 phosphorylation expression of STAT3, and AKT [35,36,37,38,39]. Here, STAT3 is linked to neoplasm.