NF1 and neoplasm: In a more recent study, Masgras et al. demonstrated how the loss of neurofibromin can result in an unbalanced intracellular NAD/NADPH ratio, with an important role for the increased intracellular NAD+, in addition to the reactivation of SIRT3 and in synergy with TRAP1 inhibition, in contrast to the proliferation of NF1-related neoplasms [97].