Metabolic conditions such as diabetes alter the expression of the protein arginine N-methyltransferase 1-asymmetric dimethylarginine-dimethylarginine dimethylamino-hydrolase (PRMT1-ADMA-DDAH) axis where adversely higher ADMA expression will result in higher PRMT1 and lower DDAH1 expressions [3,4]. The gene discussed is DDAH1; the disease is diabetes mellitus.