Therefore, to address the existing information gap, this study aims to assess the effects of sulfated polysaccharides from Caulerpa racemosa on obesity-induced cardiometabolic syndrome based on the expression of PRMT1, DDAH, and ADMA in correlation with the mTOR-SIRT1-AMPK pathways and gut microbiota modulation in an in vivo animal model. The gene discussed is SIRT1; the disease is obesity disorder.