Finally, dietary supplementation with a high dose of SPCr (2,3-di-O-methyl-1,4,5-tri-O-acetylarabinitol, 2,3,4,6-tetra-O-methyl-D-mannopyranose, and type B ulvanobiuronicacid 3-sulfate) attenuates the obesity-induced cardiometabolic syndrome via regulating the PRMT1-DDAH-ADMA with mTOR-SIRT1-AMPK pathways and gut microbiota modulation. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.