RIPK3 and acute kidney injury: In murine IRI-AKI, the upregulated expression of RIPK3 and MLKL in renal proximal tubular cells induced necroptosis and contributed to NLRP3 inflammasome activation, and Ripk3 or Mlkl deficiency reduced tubular cell necroptosis, macrophage infiltration, and NLRP3 inflammasome activation [80].