HMOX1 and Parkinson disease: Of relevance to the review, in a cellular model of PD, the use of BRUP1, an inducer of bilirubin production via the NRF2-HMOX1 axis (NRF2: nuclear factor erythroid 2-related), was found to counteract rotenone-induced neurotoxicity by suppressing ROS production and protein aggregation [85].