CNR1 and neurodegenerative disease: The presence of CB1 in the central nervous system (CNS) plays a crucial role in controlling normal synaptic activity, which, if altered, can underlie the onset of numerous pathologies, including neurodegenerative diseases and behavioral disorders [60] An important role in neuropathic pain perception is attributed to CB1, as in vivo studies showed that reducing the activity of these receptors results in increased pain sensation [61], and today, the endocannabinoid system represents one of the main targets for the modulation of pathways involved in neuropathic pain [62].