Sera from FLD patients induced a significant reduction of the expression of both NPHS2 (coding for podocin) and SYNPO genes (coding for synaptopodin); indeed, HOZ sera significantly inhibited NPHS2 expression by 65.2 ± 1.1% and SYNPO expression by 26.2 ± 9.5% when compared to control ones (p < 0.001 and p = 0.007, respectively) (Figure 4A,B). This evidence concerns the gene NPHS2 and Familial LCAT deficiency.