The presence of ACE-2 on the surface of Leydig cells is not only responsible for the testicular damage caused by infection but also has critical hormonal effects: loss of Leydig cells leads to a decrease in T levels and an increase in LH levels, resulting in the occurrence of hypergonadotropic hypogonadism [21], which is associated with a worse prognosis in COVID-19 individuals [54]. The gene discussed is PLOD1; the disease is COVID-19.