Although all moderately differentiated (G2) carcinomas (12/12; 100%) showed a progressive decrease in IR score values and a loss of nuclear localization for SIRT1 (mean IR score = 5.50 ± 0.690, range 2–9), the protein was restricted to regions where the mammary glandular morphology was still preserved (Figure 1D). The gene discussed is SIRT1; the disease is carcinoma.