For this purpose, a panel integrated by S100A8/A9 and A12 along with other analytes related to inflammation such as haptoglobin, Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4, also known as Pig major acute phase protein or Pig-MAP), and total proteins, analytes related to the immune system such as ADA, to stress such as alpha-amylase, to tissue damage such as lactate and lactate dehydrogenase (LDH), to sepsis such as aldolase and biomarkers of redox status such the ferric-reducing ability of saliva (FRAS), and advanced oxidation protein products (AOPP) will be evaluated. This evidence concerns the gene ITIH4 and Sepsis.