Moreover, a solid piece of evidence in favor of the mPTP as a major contributor to PD pathogenesis comes from a study showing that genetic ablation of CyPD in PD-linked α-Syn mutant transgenic mice delayed the disease onset and extended lifespan, thus providing a demonstration that CyPD-induced mPTP regulates the PD development [208]. This evidence concerns the gene PPIF and Parkinson disease.