PPARα regulates lipid metabolism mainly in the liver and skeletal muscle and glucose homeostasis via direct transcriptional control of the genes involved in peroxisomal/mitochondrial β-oxidation, fatty acid uptake, and triglyceride catabolism, and PPARα agonists, including fibrates, are used to treat hypertriglyceridemia. Here, PPARA is linked to hypertriglyceridemia.