In contrast, Fan et al. [50] showed an increased mRNA expression for aSyn in peripheral mononuclear cells, and Emelyanov et al. [118] showed a significant increase in aSyn levels in peripheral blood CD45+ cells in 458 PD patients compared with 353 HCs, related to rs356219 and rs356168 variants in the SNCA gene. The gene discussed is SNCA; the disease is Parkinson disease.