MTOR and endometriosis: In addition, Ren et al. demonstrated that the well-known mTOR inhibitor rapamycin may be able to inhibit the angiogenesis occurring in endometriosis, as they observed a marked reduction in VEGF levels and the density of microvessels in ectopic lesions of mice with peritoneal endometriosis following 2-week treatment with rapamycin [52].