Interestingly, HBO2 treatment has been shown to decrease the expression of NF-κB at protein level in both an LPS (liposaccharide) model of sepsis, neuroinflammation, healthy cells, and cancer cells [45,46,47], preventing the production of inflammatory cytokines and pulling in an anti-inflammatory direction under ongoing stress [46,48]. This evidence concerns the gene NFKB1 and Sepsis.