Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombosis and/or pregnancy morbidity, associated with circulating “anti-phospholipid antibodies” (aPLs), such as lupus anticoagulant (LAC), anticardiolipin antibodies (aCL) and anti-β2-glycoprotein I antibodies (aβ2GPI). Here, ACLY is linked to autoimmune polyendocrinopathy.