Recently, Wang G et al., using lupus-prone MRL+/+ mice, demonstrated that trichloroethene (TCE) exposure accelerated an autoimmune response by inducing the dysregulation of TLR signaling and the concomitant impairment of NRF2 and its target gene HO-1. The gene discussed is NFE2L2; the disease is systemic lupus erythematosus.