NFE2L2 and systemic lupus erythematosus: In an animal study, mice lacking NRF2 developed several characteristics of the autoimmune-mediated lesions, similar to those of human SLE, the spontaneous development of autoantibodies, increased T-cell proliferation, multi-tissue inflammatory lesions, along with glomerulonephritis, the intravascular deposition of immunoglobulin complexes and premature death [93].