DARPP-32 has been linked to schizophrenia molecular pathophysiology: (i) it is found reduced in animal models of psychosis and postmortem studies on schizophrenia brains [157,158,159]; (ii) its phosphorylation is modulated and increased by antipsychotic therapies such as haloperidol [160,161]. This evidence concerns the gene PPP1R1B and schizophrenia.