DRD2 and schizophrenia: Finally, dopamine receptors are also involved in crosstalk with NMDAR pyramidal and striatal neurons and interneurons: D1R activation is responsible for enhanced NMDAR-mediated Ca2+ release, whereas D2R activation inhibits NMDAR neurotransmission that could be implicated in the hypoglutamatergic transmission reported in schizophrenia and in restoring cortical–striatal connectivity and synaptic plasticity, relevant for cognitive processes [151,179,180].