After the deletion of SIRT5, the oxygen consumption in mitochondria significantly reduced, and PKCε could not prevent cortical degeneration after cerebral ischemia injury, strongly suggesting that SIRT5 plays an important role in the regulation of mitochondrial energy generation and the neuroprotective effect after cerebral ischemia mediated by PKCε [71]. This evidence concerns the gene SIRT5 and Cerebral ischemia.