CD274 and cancer: For advanced TNBC patients in which the cancer cells express the PD-L1 protein, pembrolizumab (brand name: Keytruda) [39], a PD-1 monoclonal antibody, and atezolizumab (brand name: Tecentriq) [40], a PD-L1 monoclonal antibody, have, in combination with chemotherapy, been approved; however, the frequency of genetic defects resulting in microsatellite instability and defects in mismatch repair is very low in TNBC [41,42], limiting the reach of immunotherapy for TNBC patients.