Additionally, the amyotrophic-lateral-sclerosis-associated, aggregation-prone RNA-binding protein TAR DNA-binding protein 43 (TDP-43) was reported to alter VAPB–RMND3 interaction [153], suggesting a convergence of several pathways for neurodegeneration in amyotrophic lateral sclerosis involving this tether pair. This evidence concerns the gene VAPB and amyotrophic lateral sclerosis.