SIRT1 and Parkinson disease: Additionally, resveratrol was shown to enhance autophagic α-synuclein degradation by stimulating AMPK or via the activation of sirtuin-1 and LC-3 deacetylation in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD [66].