The administration of polyphenol oleuropein aglycone has been shown to improve autophagic reactions and prevent or delay the occurrence of AD in CRND8 AD transgenic mice by increasing the expression of beclin-1, LC3-I and II, p62 [51] and by regulating the mammalian target of rapamycin (mTOR). The gene discussed is BECN1; the disease is Alzheimer disease.