NR1H3 and cancer: The differential LXRα expression patterns between cancer and adjacent normal tissues are shown in Figure 2B. The level of LXRα was found to be significantly lower in breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), kidney chromophobe (KICH), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC) than in adjacent normal tissues.