Moriishi et al. proved that the hepatitis C virus (HCV) core protein could be degraded by the proteasome activator PA28γ and activate sterol-regulatory-element-binding protein (SREBP)-1c promoter via an LXRα/RXRα-dependent pathway, eventually accelerating the development of hepatic steatosis and HCC [56]. The gene discussed is NR1H3; the disease is fatty liver disease.