The results of single-cell RNA sequencing suggested that triple-negative breast cancer (TNBC) tumor-resident immune cells showed a high expression of LXRα, and Seurat cell-cluster analysis showed that LXRα expression was most induced in the “myeloid cell” cluster, suggesting that the upregulation of LXRα may be associated with tumor cell–immune cell interactions in TNBC. This evidence concerns the gene NR1H3 and neoplasm.