At the same time, lipogenic targets of LXRα were also overexpressed, such as peroxisome-proliferator-activated receptor-γ (PPAR-γ), SREBP-1c, SREBP-2, and fatty acid synthase (FAS), suggesting that these genes might be involved in HCC carcinogenesis [57]. Here, NR1H3 is linked to hepatocellular carcinoma.