Moreover, another study suggested that LXRα could enhance the stability of the suppressor of cytokine signaling 3 (SOCS3) mRNA and elevate the level of SOCS3, resulting in a decline in cyclinD1 and an increase in p21 and p27, eventually leading to cell cycle arrest at the G1/S phase and inhibiting the growth of HCC cells [64]. Here, NR1H3 is linked to hepatocellular carcinoma.