AGTR1 and neoplasm: When the tumor samples were ranked according to the grading, the AT-1R mRNA increased 1.3-fold in the well-differentiated tumors (G1; p < 0.01) while it gradually decreased in the poorly and very poorly differentiated tumors, reaching a 2.9-fold decrement (G4; p < 0.01) compared with the normal kidney tissues (Figure 1b).